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Monitoring of brain tissue pressure with a fiberopticdevice. Bothcompounds are 98% plasma protein bound, donot enter brain and are excreted by the kidney.The plasma t? of losartan is 2 hr, but that ofE3174 is 6–9 hr

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Ubiquitin is a 76 amino acid pro-tein that is conjugated to lysines in target proteins either as monoubiquitination,which can occur as single ubiquitins on multiple sites or chains of up to threeubiquitin molecules on each site, or as polyubiquitination which is designated aschains of at least 4 ubiquitin molecules linked together on one or more lysines(reviewed in [ 24]).

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